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Population pharmacokinetic approach to evaluate the effect of CYP2D6, CYP3A, ABCB1, POR and NR1I2 genotypes on donepezil clearance

机译：人群药代动力学方法评估CYP2D6，CYP3A，ABCB1，POR和NR1I2基因型对多奈哌齐清除率的影响

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摘要

A large interindividual variability in plasma concentrations has been reported in patients treated with donepezil, the most frequently prescribed antidementia drug. We aimed to evaluate clinical and genetic factors influencing donepezil disposition in a patient population recruited from a naturalistic setting.

机译：据报道，用多奈哌齐治疗的患者血浆中浓度存在较大的个体差异，多奈哌齐是最常开处方的抗痴呆药物。我们旨在评估影响从自然主义环境招募的患者人群中多奈哌齐治疗的临床和遗传因素。

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Noetzli, Muriel; Guidi, Monia; Ebbing, Karsten; Eyer, Stephan; Wilhelm, Laurence; Michon, Agnès; Thomazic, Valérie; Stancu, Ioana; Alnawaqil, Abdel-Messieh; Bula, Christophe; Zumbach, Serge; Gaillard, Michel; Giannakopoulos, Panteleimon; von Gunten, Armin; Csajka, Chantal; Eap, Chin Bin;
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年度 2014
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1. Population pharmacokinetic approach to evaluate the effect of CYP2D6, CYP3A, ABCB1, POR and NR1I2 genotypes on donepezil clearance [J] . NoetzliM., GuidiM., EbbingK., British Journal of Clinical Pharmacology . 2014,第1期

机译：人群药代动力学方法评估CYP2D6，CYP3A，ABCB1，POR和NR1I2基因型对多奈哌齐清除率的影响
2. Population pharmacokinetic approach to evaluate the effect of CYP2D6, CYP3A, ABCB1, POR and NR1I2 genotypes on donepezil clearance [J] . Noetzli Muriel, Guidi Monia, Ebbing Karsten, British journal of clinical pharmacology . 2014,第1期

机译：人口药代动力学方法评价CYP2D6，CYP3A，ABCB1，POR和NR1I2基因型对多奈哌齐的影响
3. Effect of the CYP3A5, CYP3A4, CYP3A7, ABCB1, POR and NR1I2 genes in the pharmacokinetics of tacrolimus in a pediatric cohort with stable serum concentrations after renal transplantation: study protocol. [J] . Irene Dapía García, Aleksandra Tabakov, Laura Espinosa Roman, IBJ Clinical Pharmacology . 2017,第005期

机译：CYP3A5，CYP3A4，CYP3A7，ABCB1，POR和NR1I2基因对他克莫司在肾移植后血清浓度稳定的儿童队列中他克莫司药代动力学的影响：研究方案。
4. CYP2D6, GYP2C19, CYP2C9 and CYP3A5 polymorphism in the Spanish population [C] . Llovo R., Tudoli I., Carril J.C, International Conference on Alzheimer's and Parkinson's Diseases . 2009

机译：CYP2D6，GYP2C19，CYP2C9和CYP3A5在西班牙语人群中的多态性
5. Population pharmacokinetics and efficacy of ribavirin in patients with chronic hepatitis C genotype 1 infection. [D] . Jin, Runyan. 2010

机译：利巴韦林在慢性丙型肝炎基因型1感染患者中的群体药代动力学和功效。
6. Population pharmacokinetic approach to evaluate the effect of CYP2D6 CYP3A ABCB1 POR and NR1I2 genotypes on donepezil clearance [O] . Muriel Noetzli, Monia Guidi, Karsten Ebbing, 2014

机译：人群药代动力学方法评估CYP2D6CYP3AABCB1POR和NR1I2基因型对多奈哌齐清除率的影响
7. Influence of CYP2D6 ,CYP3A4 ,CYP3A5 and ABCB1 Polymorphisms on Pharmacokinetics and Safety of Aripiprazole in Healthy Volunteers [O] . Carmen Belmonte, Dolores Ochoa, Manuel Román, 2018

机译：CYP2D6，CYP3A，CYP3A5和ABCB1多态性对健康志愿者中Aripiprazole的药代动力学和安全性的影响

Population pharmacokinetic approach to evaluate the effect of CYP2D6, CYP3A, ABCB1, POR and NR1I2 genotypes on donepezil clearance

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